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. 2017 Dec 22;7:18049. doi: 10.1038/s41598-017-18143-x

Figure 8.

Figure 8

TRPC4-dependent [Ca2+]i elevation and CaMKII/CREB activation contribute to high glucose-induced GMC proliferation. (A) Phase contrast images, and (B) Cell growth curves showing that high glucose-induced mouse GMC proliferation is reduced by ML204 (100 nM), BAPTA (2 µM), KN-93 (2 µM), and SGC-CBP30 (1 µM). n = 10 each; “n” denotes the number of wells. Each time point represents four independent scans per well of the microplates. **P < 0.05 vs. HG (42–72 h); ##P < 0.05 vs. HG (44–72 hr); *P < 0.05 vs. HG (38–72 hr); #P < 0.05 vs. HG (36–72 hr); Scale bar = 300 µm. HG (high glucose); NG (normal glucose).