Table 2.
LUCS as a cell acute toxicity assay.
| Cell model | Assay | R2 | a | N | Ref. |
|---|---|---|---|---|---|
| 3T3 | NRU | 0.80 | 0.94 | 53 | 13 + Fig. 2 |
| NHK | NRU | 0.75 | 0.98 | 48 | 14 |
| Fa32 | NRU | 0.80 | 1.00 | 51 | 14 |
| 3T3 | MTT | 0.88 | 1.04 | 27 | 15 |
| Rat hepatocytes | MTT | 0.75 | 1.00 | 31* | 15 |
| HepG2 | MTT | 0.81 | 1.05 | 27 | 15 |
| HepG2 | PI | 0.92 | 1.09 | 16 | 15 |
| SHS-SY5Y | PI | 0.83 | 0.97 | 25 | 15 |
Regression analysis of Log EC50 s obtained from HepG2 LUCS versus indicated assays using substances of the ACuteTox European Program databank. R2, determination coefficient; a, regression line slope; N, number of substances analyzed; NRU, Neutral Red Uptake; MTT, 3-(4,5-di Methyl Thiazol-2-yl)-2,5-diphenyl Tetrazolium bromide; PI, Propidium Iodide; *when malathion, a strong outlier in this series of data, is included: R2 = 0.67, a = 0.99, N = 32.