Table 2.
Allele, genotype frequency and risk alleles of FTO SNPs in cases (obese) and controls (non-obese): Tehran Lipid and Glucose Study.
| Frequency | Normal BMIa (n = 627) | Obeseb (n = 627) | Risk allelec | Effect size (odds ratio) |
|---|---|---|---|---|
| rs1121980 | 1.34 | |||
| Allele | A: 38 (463) C | A: 39(474) | A | |
| G: 62(755) | G: 61(752) | |||
| Genotype | AA: 15(92) | AA: 13(77) | ||
| GA: 46(279) | GA: 52(320) | |||
| GG: 39(238) | GG: 35(216) | |||
| rs1421085 | 1.43 | |||
| Allele | C: 37(458) | C: 36(446) | C | |
| T: 63(770) | T: 64(792) | |||
| Genotype | CC:14(87) | CC:12(72) | ||
| TC: 44(272) | TC: 51(314) | |||
| TT: 42(260) | TT: 37(228) | |||
| rs9939973 | 1.10 | |||
| Allele | A: 37.9 (468) | A: 38.2 (469) | A | |
| G: 62.1 (768) | G: 61.8 (759) | |||
| Genotype | AA: 15(93) | AA: 12.2(76) | ||
| GA: 45.6(282) | GA: 52(319) | |||
| GG: 39.3(243) | GG: 35.8(220) | |||
| rs8050136 | 1.25 | |||
| Allele | A:34(417) | A: 35(435) | A | |
| G: 66(823) | G: 65(795) | |||
| Genotype | AA: 13(78) | AA: 11(66) | ||
| GA: 42(261) | GA: 49(303) | |||
| GG: 45(281) | GG: 40(246) | |||
| rs17817449 | 1.54 | |||
| Allele | G: 33(413) | G: 36(444) | G | |
| T: 67(832) | T: 64(802) | |||
| Genotype | GG: 12(75) | GG: 11(68) | ||
| TG: 42(264) | TG: 49(308) | |||
| TT: 46(284) | TT: 40(247) | |||
| rs3751812 | 1.52 | |||
| Allele | G: 67(829) | G: 65(799) | T | |
| T: 33(405) | T: 35(427) | |||
| Genotype | GG: 47(290) | GG: 40(247) | ||
| GT: 40(249) | GT: 50(305) | |||
| TT: 13(78) | TT: 10(61) |
aBMI (body mass index): 18.5–25 kg/m2, bBMI ≥ 30 kg/m2, C% (n)
All allele frequencies were in Hardy-Weinberg equilibrium (P > 0.2), except allele frequency of rs9939973 in obese participants (P = 0.01).
cRisk allele based on data from GWAS catalog (The NHGRI-EBI Catalog of published genome-wide association studies) and the Phenotype-Genotype Integrator44,45.
Effect sizes were derived from the previous literature and reported meta-analysis46,49,52.