Table 3.
Adjusted ORs (95%CI) for obesity according to quartiles of dietary fiber intake and FTO SNP genotypesa (Tehran Lipid and Glucose Study).
| Q1 | Q2 | Q3 | Q4 | P for trend | P for interaction | |
|---|---|---|---|---|---|---|
| rs1121980 | 0.15 | |||||
| GG | 0.96 (0.54–1.69) | 0.90 (0.53–1.54) | 0.85 (0.50–1.47) | 1 | 0.36 | |
| GA + AA | 1.47 (1.02–2.03) | 1.14 (0.75–1.83) | 1.05 (0.65–1.71) | 0.58 (0.11–1.17) | 0.03 | |
| rs1421085 | 0.85 | |||||
| TT | 0.82 (0.47–1.42) | 0.88 (0.52–1.49) | 0.79 (0.46–1.34) | 1 | 0.27 | |
| TC + CC | 1.37 (0.83–2.18) | 1.14 (0.52–1.81) | 1.00 (0.51–1.68) | 0.73 (0.51–1.39) | 0.06 | |
| rs9939973 | 0.70 | |||||
| GG | 0.91 (0.52–1.58) | 0.86 (0.50–1.46) | 0.83 (0.49–1.43) | 1 | 0.22 | |
| GA + AA | 1.59 (1.12–2.16) | 1.15 (0.70–1.77) | 1.02 (0.63–1.65) | 0.65 (0.23–1.37) | 0.05 | |
| rs8050136 | ||||||
| GG | 0.85 (0.50–1.43) | 0.75 (0.45–1.25) | 0.98 (0.61–1.58) | 1 | 0.25 | 0.02 |
| GA + AA | 1.95 (1.57–2.54) | 1.21 (0.91–1.93) | 0.90 (0.57–1.52) | 0.62 (0.21–1.12) | 0.009 | |
| rs1781749 | ||||||
| TT | 0.79 (0.47–1.32) | 0.76 (0.46–1.27) | 0.62 (0.37–1.04) | 1 | 0.21 | 0.02 |
| TG + GG | 1.88 (1.65–2.37) | 1.17 (0.83–1.87) | 0.79 (0.47–1.31) | 0.41 (0.15–0.97) | 0.001 | |
| rs3751812 | ||||||
| GG | 0.80 (0.48–1.35) | 0.71 (0.43–1.19) | 0.61 (0.37–1.02) | 1 | 0.36 | 0.01 |
| GT + TT | 1.65 (1.27–2.22) | 1.25 (0.68–1.73) | 1.24 (0.67–1.73) | 0.32 (0.11–0.94) | 0.03 | |
OR: Odds Ratio, Q: Quartiles of dietary fiber intake (Q1: < 7.06, Q2: 7.06–9.13, Q3: 9.14–11.26, Q4 > 11.26 g/4186 KJ), FTO: Fat mass and Obesity associated gene, SNP: Single Nucleotide Polymorphism. aORs (95% CI) were calculated using conditional logistic regression model, adjusted for education level and energy intake. Participants were classified (8 groups) according to quartiles of dietary fiber intake and genotypes. The highest quartile of dietary fiber intake and homozygote genotype of major allele was used as the reference group.