Table 6.
Adjusted ORs (95%CI) for obesity and abdominal obesity according to categories of dietary fiber intake and GRSa.
| Quartiles of dietary fiber intake | Low fiber intake | High fiber intake | P for trend | P for interaction | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | P for trend | P for interaction | < 14 gr | ≥ 14 gr | |||
| Obesity | 0.01 | 0.004 | ||||||||
| GRS ≥ 6 | 1.83 (1.32–2.54) | 1.30 (0.81–2.07) | 0.80 (0.49–1.32) | 0.67 (0.41–1.10) | 0.004 | 2.74 (2.40–3.35) | 1 | 0.0005 | ||
| GRS < 6 | 1.27 (0.80–2.01) | 0.82 (0.52–1.31) | 0.80 (0.49–1.30) | 1 | 0.71 | 0.64 (0.29–1.45) | 0.55 (0.29–1.02) | 0.34 | ||
| Abdominal obesity | 0.38 | 0.83 | ||||||||
| GRS ≥ 6 | 1.00 (0.62–1.62) | 0.88 (0.54–1.37) | 0.79 (0.46–1.32) | 0.70 (0.44–1.12) | 0.07 | 1.13 | 1 | 0.55 | ||
| GRS < 6 | 0.99 (0.60–1.64) | 1.10 (0.66–1.82) | 1.23 (0.75–2.02) | 1 | 0.68 | 0.98 (0.69–1.38) | 0.89 (0.56–1.40) | 0.70 | ||
| High WHR | 0.14 | 0.06 | ||||||||
| GRS ≥6 | 1.29 (0.63–2.64) | 1.41 (0.54–1.37) | 1.68 (0.83–3.37) | 1.13 (0.53–2.40) | 0.93 | 0.86 (0.14–2.15) | 1 | 0.70 | ||
| GRS < 6 | 1.84 (0.90–3.77) | 2.12 (1.05–4.30) | 1.86 (0.91–3.81) | 1 | 0.06 | 2.45 (1.64–3.94) | 2.13 (1.21–3.75 | 0.03 | ||
OR: Odds Ratio, Q: Quartiles of dietary fiber intake (Q1: < 7.06, Q2: 7.06–9.13, Q3: 9.14–11.26, Q4 > 11.26 g/4186 KJ), GRS: Genetic risk score, was calculated on the basis of the 6 selected single nucleotide polymorphisms of fat mass and obesity associated gene (FTO) using a weighted method. ORs (95% CI) were calculated using conditional logistic regression model, adjusted for education level and energy intake. Participants were classified (8 groups) according to quartiles of dietary fiber intake and GRS. The highest quartile of dietary fiber intake and GRS < 6 was used as the reference group; also participants were classified (4 groups) according to low and high fiber intake and GRS. The high fiber intake and GRS > 6 was used as the reference group.