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Phase contrast microscopy of morphological changes in HPMCs. HPMCs cultured in control medium exhibited a cobblestone-like growth pattern. HPMCs treated with TGF-β1 (5 ng/mL) for 72 h exhibited a spindle fibroblast-like morphology. Pretreatment with 200 and 400 μM tranilast prevented spindle-like changes induced by TGF-β1 and resulted in rounding of the cells. Original magnification × 400
