Figure 7. Heterogeneous loss of CCL2, the CCR2 ligand, extends survival of glioblastoma bearing mice.
(A) Survival curve of GBM patients stratified according to their CCL2 expression queried from the TCGA databank. (B) Diagram illustrating the generation of tumors in Ccl2+/− mice using RCAS/Ntva system. (C) Survival curve of tumor-bearing Ntva+ mice. N is denoted in the figures. * P<0.05 by Mantel-Cox test.