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. 2017 Dec 22;8:289. doi: 10.1186/s13287-017-0734-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Mice treated with MSCs show reduced inflammatory markers. The pro-inflammatory factors tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), and the anti-inflammatory factor IL-10 in the serum were detected by luminescence. The serum showed a significant increase in IL-6 (a) and TNF-α (b) in the sepsis group compared with the levels in the sham group. A significant decrease in TNF-α and IL-6 was observed in the sepsis + mesenchymal stem cell (MSC) group compared with the levels in the sepsis group. Furthermore, the serum showed a significant increase in IL-10 (c) in the sepsis group compared with the levels in the sham group, and a greater increase in the sepsis + MSC group when compared with the septic group. Data represent the mean ± SEM, n = 10. ^### p < 0.001, versus sham group; **p < 0.01, ***p < 0.001, versus sepsis group