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. 2017 Dec 22;14:258. doi: 10.1186/s12974-017-1033-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Pretreatment with donepezil promoted phagocytic activity of mouse primary microglial cells through the PI3K but not MAPK/ERK pathway. a Representative images showing that pretreatment with donepezil promoted phagocytic activity of mouse primary microglial cells through the PI3K but not MAPK/ERK pathway. Images shows bright field (left), FITC (middle) and Overlay (right), respectively. b Bar graphs showing that pretreatment of 5 μM donepezil for 12 h enhanced the phagocytic activity of mouse primary microglial cells to about 105% control. In addition, pretreatment with donepezil and LY294002 (10 μM) but not PD98059 (10 μM) for 12 h significantly suppressed the donepezil-induced promotion of phagocytic activity