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. 2017 Dec 16;23:5951–5959. doi: 10.12659/MSM.907592

Figure 5.

Figure 5

Melatonin reduces neuronal apoptosis in a PLC-mediated manner. (Top panels) Representative TUNEL staining images from the (A) hippocampus and (B) cortex. Black scale bar=10 μm. (Bottom panels) PHZ-induced neonatal hemolytic hyperbilirubinemia significantly increased (A) hippocampal apoptosis levels and (B) cortical apoptosis levels. Melatonin therapy partially rescued (A) hippocampal apoptosis levels and (B) cortical apoptosis levels. Pre-treatment with the PLC inhibitor U73122 abolished effects of melatonin on (A) hippocampal apoptosis levels and (B) cortical apoptosis levels. All experiments were performed in triplicate. Data are reported as means ± standard errors of the mean (SEMs). * p<0.05 vs. control group; # p<0.05 vs. PHZ group, $ p<0.05 vs. PHZ + melatonin group.