Table 1.
Construction of the neonatal hemolytic hyperbilirubinemia model.
| Day 1 | Day 2 | Day 3 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Time point | 8: 00 AM | 8: 30 AM | 9: 00 AM | 8: 00 AM | 8: 30 AM | 9: 00 AM | 8: 00 AM | 8: 30 AM | 2: 00 PM |
| Control group | Saline* | Saline | Saline | Saline | Saline | Saline | Saline | Saline | Sacrifice |
| PHZ group | Saline | Saline | PHZ# | Saline | Saline | PHZ# | Saline | Saline | Sacrifice |
| PHZ + melatonin group | Saline | Melatonin‡ | PHZ# | Saline | Melatonin@ | PHZ# | Saline | Melatonin@ | Sacrifice |
| PHZ + melatonin + U73122 group | U73122§ | Melatonin‡ | PHZ# | U73122§ | Melatonin@ | PHZ# | U73122§ | Melatonin@ | Sacrifice |
*
10 ml/kg saline intraperitoneal (i.p.) injection;
#
75 mg/kg PHZ intraperitoneal (i.p.) injection;
@
10 mg/kg melatonin intraperitoneal (i.p.) injection;
§
1 μg U73122 intracerebral (i.c.) injection.