Fig. 1.

Diagram of APP illustrating nine FAD mutations that have been incorporated into mouse models. The Aβ domain is highlighted in red, with the β- and γ-cleavage sites identified at residues 671 and 714, respectively, using the numbering convention for full-length 770 amino acid protein. The amino acid sequence of Aβ is outlined in red, with the positions of several commonly used FAD mutations and their amino acid substitutions shown (in bold) alongside the geographic name identifying each variant. Italic residues indicate the three sites at which the Aβ sequence diverges between human and mouse (human is shown). Swe, Swedish; Arc, Arctic; Aus, Austrian; Lon, London; Ind, Indiana; Ibe, Iberian; Flo, Florida