Table 2.

Lines with physiological expression of APP, PS1, and Tau

Model	Allele	Targeting approach	Availability	Reference
APPNLh	endogenous mouse App with Swe mutation and humanized Aβ domain	Knock-in	NA	[89]
APP R1.40	complete human genomic APP (Swe)	YAC transgenic	MMRRC 34831-JAX	[86]
APPSL	mouse/human App hybrid with humanized Aβ domain (Swe/Lon)	Knock-in	NA	[92]
APPDSL	endogenous mouse App with humanized Aβ domain (Swe/Dutch/Lon)	Knock-in	Hui Zheng	[57]
APPNL, APPNLF, and APPNLGF	endogenous mouse App with humanized Aβ domain and (Swe (NL), Swe/Ibe (NLF), or Swe/Arc/Ibe (NLGF))	Knock-in	Takaomi Saido	[58]
PS1M146V	endogenous mouse Psen1 (M146 V)	Knock-in	JAX 004193	[214]
PS1 KI	endogenous mouse Psen1 (P264L)	Knock-in	NA	[215]
htau	complete human genomic MAPT (wt) with targeted disruption of murine Mapt	PAC transgenic x Mapt KO	JAX 005491	[37]

Tables 1-4: Refer to Fig. 1 for illustration of APP mutations