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. 2017 Dec 22;18:986. doi: 10.1186/s12864-017-4351-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Network analysis based on protein-protein interactions for the human orthologues associated with the significant enrichment for obesity. Human orthologues of the 32 rat genes assigned to promoters with SSVs overlapping the selected HVRs in the LH strain and associated with obesity were analysed (black circles). Relationships among these genes were investigated using GeneMANIA (see Methods). The grey circles are genes predicted by GeneMANIA to be in the network. Of 20 significant GO Terms (q-value <0.05) total, two are presented in the figure due to their significance and the number of genes included in each module (green circles: ‘Circadian rhythm’, q-value <1e-8; red circles: ‘Negative regulation of TGF-beta receptor signalling pathway’, q-value <0.01)