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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Nanomedicine. 2017 Sep 7;14(1):51–61. doi: 10.1016/j.nano.2017.08.017

Figure 1. The synthesis and fabrication schemes of (A) biotin-conjugated cholesterol, (B) biotin-conjugated vitamin A, (C) biotin-conjugated IGF2R-speific peptide, and (D) the neutravidin-based siRNA nanocomplex.

Figure 1

Biotin-conjugated PCBP2 siRNA, neutravidin and biotin-conjugated ligands were mixed in a 2:1:2 ratio at room temperature to form the siRNA-neutravidin-ligand complex, followed by condensation with protamine to form the final nanocomplex