Cellular uptake of the nanocomplexes in quiescent and activated primary rat HSCs. Cellular uptake of the SNCP, SNVP and SNPP nanocomplexes containing Alexa Flour 647 labeled siRNA were evaluated in quiescent primary rat HSCs at the 5th passage generation (A, B, and C) and activated primary rat HSCs at the 16th passage generation (D, E, and F). (A, D) Percent of the cells that take up the nanocomplexes; (B, E) Fluorescence intensity of the cells that take up the nanocomplexes; (C, F) Confocal images of the cells. All results are presented as the mean ± SD (n=3). (*P<0.05; **P<0.01).