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. 2017 Dec 18;50(1):20–25. doi: 10.1038/s41588-017-0010-y

Fig. 2. Copy number variation of Cyp6a17 and its functional consequences.

Fig. 2

a, Cyp6a17 is deleted in the A4 genome relative to the ISO1 genome. Alignment between annotated ISO1 and A4 assemblies on chromosome arm 2R shows a large ISO1 region (red) missing in A4. Gene models are shown (gray indicates noncoding sequences, and yellow indicates coding sequences). b, Temperature preference of strains A4 (∆Cyp6a17) and w 1118 (intact Cyp6a17 23). Preference was measured by recording the position of 100 flies along a linear 8 °C–30 °C temperature gradient after an adjustment period (Methods). Each dot represents the position of a fly along the gradient. Each experiment number is an independent pairwise trial. A4 flies occupy colder regions of the gradient than w 1118 flies (Fisher’s method on Wilcoxson rank-sum tests, meta P value << 10−16). Upper and lower hinges of the box plots represent 25% and 75% quantiles, respectively; the upper whisker indicates the largest observation less than or equal to the upper hinge + 1.5 times the interquartile range (IQR); the lower whisker indicates the smallest observation greater than or equal to the lower hinge – 1.5 times the IQR; and the middle horizontal bar indicates the median, 50% quantile. c, Frequency of the Cyp6a17 deletion in African (DPGP2) and North American (DGRP) populations.