Table 2.
Diffusion weighted experimental parameters.
| Condition | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|
| Application | Rat/Simulation | Rat/Simulation | Rat | Rat | Human |
| Readout | PRESS | PRESS | EPI | EPI | EPI |
| EPI Segments | – | – | 4 | 4 | 1 |
| rFOV | – | – | – | 2DRF | 2DRF |
| TR (ms) | 3,000 | 3,000 | 1,500 | 1,500 | 2,000 |
| TE (ms) | 41 | 41 | 61 | 35 | 86 |
| FOV (mm2) | 10 | 10 | 25.6 × 25.6 | 13.5 × 9.6 | 200 |
| Voxel/Slice thickness (mm) | 6 | 6 | 1.5 | 1.5 | 5 |
| In-plane resolution | – | – | 266 × 400μm2 | 150μm2 | 1.43 mm2 |
| DWI Schemea | 5-design DDE | DDE Filter-Probe | DDE Filter-Probe | SDE Filter-Probe | SDE Filter-Probe |
| DWI Acquisitions | 72 | 36 | 36 | 36 | 36 |
| Max total b-value (s/mm2) | 4,000 | 4,000 | 4,000 | 3,000 | 3,000 |
| Diffusion separation Δ (ms) | 12 | 12 | 12 | 12 | 32.5 |
| Diffusion duration (ms) | 6 | 6 | 6 | 6 | 25.4 |
| Mixing Time (τ; ms) | 6 | 6 | 6 | – | – |
| NEX | 1 | 1 | 2 | 2 | 6 |
| Acquisition Time | 3:48 | 2:09 | 5:36 | 5:36 | 5:26 |
| Outcome Measure(s) | Eccentricity (μm4) | ADC|| (μm2/ms) fR (fraction) | ADC|| (μm2/ms) | ADC||(μm2/ms) | ADC|| (μm2/ms) |
a
From Table 1.