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. 2017 Dec 19;8:921. doi: 10.3389/fphar.2017.00921

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Copyright © 2017 Silva-Cruz, Carlström, Ribeiro and Sebastião.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibitors of the hydrolysis of 2-AG or of anandamide differently affect strong-θ-burst induced LTP. (A) Time course of the averaged fEPSP slopes, and original traces of fEPSP recordings, in control conditions (no drugs) or in the presence of 1 μM JZL 184 (inhibitor of the enzyme that hydrolyses 2-AG, MAGL), 1 μM URB597 (inhibitor of the enzyme that hydrolyses anandamide, FAAH), or in the presence of 1 μM JZL 195 (inhibitor of FAAH and MAGL). (B) Quantification of LTP magnitude under the indicated drug conditions. Data in control conditions, in panels (A) and (B), are the same as shown in Figures 2A,B, but are represented in this figure to allow comparison with the drug conditions. ^∗p < 0.05 (F_(3,42) = 10.3, one-way ANOVA with Sidak’s correction). For further details see legend to Figure 1.