Skip to main content
. 2017 Dec 19;8:921. doi: 10.3389/fphar.2017.00921

FIGURE 5.

FIGURE 5

The enhancement LTP caused by physiologically released eCBs does not result from enhanced adenosinergic tonus on A1R. (A) Data obtained in slices taken from A1R KO mice, LTP being induced by a strong-θ-burst in control conditions (no drugs, blue symbols and traces) or in the presence of 1 μM of AM251 (red symbols and traces). (B) Data obtained in slices from wild-type mice in the presence of the A1R antagonist, DPCPX (50 nM) either in the absence (blue symbols and traces) or presence (pink symbols and traces) of AM251 (1 μM). (C) Quantification of LTP magnitude under the indicated conditions. In all cases LTP was induced by a strong-θ-burst. Data from WT mice in the absence of DPCPX (control WT, AM251 WT, panel C) are the same as that shown in Figure 2B, but is represented in this figure to allow comparisons with data from A1R KO mice and with data from WT slices in the presence of DPCPX. ∗∗p < 0.01; ∗∗∗p < 0.001 (F(5,62) = 10.0, one-way ANOVA with Sidak’s correction). For further details see legend to Figure 1.