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. 2017 Dec 19;8:921. doi: 10.3389/fphar.2017.00921

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Copyright © 2017 Silva-Cruz, Carlström, Ribeiro and Sebastião.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Input/output curves where fEPSP slopes values are plotted against the stimulation intensities (80 and 300 μA) in hippocampal slices under the drug conditions indicated. All values in the figure are represented as the mean ± SEM, n = (5–8). Statistical significance was assessed by two-way ANOVA followed by Sidak’s post hoc test, comparing multiple experimental groups; no significant differences among drug treatments were detected except for the WIN; ^∗p < 0.05 as compared with the other drugs) (F_{interaction(44,360)} = 0.5, F_{row factor(11,360)} = 38.1, F_{column factor(4,360)} = 14.4, t-values: control/AM251 – 0.6, control/WIN – 5.2, control/Rimonabant – 1.1, control/Orlistat – 2.1).