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. 2017 Dec 19;11:400. doi: 10.3389/fncel.2017.00400

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Copyright © 2017 Wei, Mei, Xia and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of different concentrations of 2-APB on TG-induced Ca²⁺ entry in DRG neurons transfected with Orai1 and Orai3 siRNA. (A) Representative traces of SOCE in neurons treated with control siRNA and Orai1 plus Orai3 siRNAs. (B) Summary of effects of control siRNA (n = 21) and Orai1 plus Orai3 siRNAs (n = 12) on SOCE in DRG neurons. (C) RT-qPCR confirming that both Orai1 and Orai3 were significantly knocked down by transfection with Orai1 plus Orai3 siRNAs. (D–F) Effects of vehicle (control), 3 and 30 μM 2-APB on SOCE in DRG neurons transfected with control siRNA (D), Orai1 siRNA (E) Orai3 siRNA (F), n = 14–29. Values represent mean ± SEM; ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 compared with control group by Student’s t-test.