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. 2017 Dec 19;11:400. doi: 10.3389/fncel.2017.00400

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Copyright © 2017 Wei, Mei, Xia and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation of SOCs by TG increases neuronal excitability in DRG neurons. (A) Representative action potentials recorded in DRG neurons before (Pre TG), 5 min after TG application (TG), and 3 min after GdCl₃ addition (TG+GdCl₃). (B) Summary of TG-induced changes in spike frequency, membrane potential, and input resistance and attenuation by GdCl₃ in DRG neurons. (C) Representative action potentials recorded in DRG neurons before (Pre TG), 5 min after TG application (TG), and 3 min after synta66 addition (TG+synta66). (D) Summary of TG-induced changes in spike frequency, membrane potential, and input resistance and attenuation by synta66 in DRG neurons. Values represent mean ± SEM; n = 6–12 neurons; ^∗P < 0.05, ^∗∗∗P < 0.001 compared with Pre TG group, ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 compared with TG group by Student’s t-test.