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. 2017 Dec 19;11:400. doi: 10.3389/fncel.2017.00400

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Copyright © 2017 Wei, Mei, Xia and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Orai1 and Orai3 are required for TG-induced modulation of neuronal excitability in DRG neurons. (A) TG-induced modulation of action potentials before (Pre TG) and 5 min after TG application in DRG neurons transfected with control siRNA, n = 8. (B) TG-induced modulation of action potentials before (Pre TG) and 5 min after TG application in DRG neurons transfected with Orai1 siRNA plus Oria3 siRNA, n = 8. Values represent mean ± SEM; ^∗∗P < 0.01, ^∗∗∗P < 0.001 compared with Pre TG group by Student’s t-test.