Figure 5.

Toll-like receptor 7 signaling augments memory function during recall responses. (A) Immunization and adoptive transfer scheme for secondary challenge. Mice were immunized with NP-CGG or NP-CGG plus R837. Forty days later, spleen cells were adoptively transferred into muMT mice. One day after transfer, recipients were boosted with NP-CGG, and spleens and sera were analyzed 5 days later. (B) Germinal center cells. (C) Plasmablasts. (D) Plasma cells. (E) Serum NP-specific IgG1 bound to NP₃₀-BSA. Each symbol represents a muMT recipient mouse from four independent experiments with one to three mice each. Bar indicates mean; p-value determined by two-tailed Student’s t-test.