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. 2017 Dec 19;8:1852. doi: 10.3389/fimmu.2017.01852

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Copyright © 2017 Yu, Bao, Wang, Gong, Chen, Guan, Le, Su, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of cathelin-related antimicrobial peptide (CRAMP) in Müller glial cells (MGCs) and in the retina of mice with streptozotocin (STZ)-induced diabetic retinopathy (DR). CRAMP was measured by immunofluorescence in isolated primary mouse MGCs and in the retina of normal (Nor) and diabetic (DR) mice. (A) Increased level of CRAMP (green) fluorescence intensity in MGCs under high glucose (HG) compared with cells under normal glucose (NG). (B) Relative intensity of CRAMP immunofluorescence. *Indicates significantly (p < 0.05) increased CRAMP in MGCs cultured in HG compared with cells in NG. (C) Immunofluorescence of CRAMP (green) in normal and DR mouse retinas. (D) Relative intensity of CRAMP immunofluorescence in mouse retinal sections. *Indicates significantly (p < 0.05) increased CRAMP intensity in DR mouse retina compared with normal mouse retina. Scale bar: 50 µm.