Table 1.
Scaling factors for optimized models.
| Objective | Ks | Kr | CaL | NCX | NaK | NaL | NaLLQT3 |
|---|---|---|---|---|---|---|---|
| Multi-variable | 8.09 | 1.17 | 3.57 | 3.05 | 1.91 | 1.70 | 4.17 |
| APDLQT | 9.71 | 1.42 | 9.59 | 1.75 | 7.40 | 4.86 | 2.28 |
The optimization gave estimated parameters for scaling of the currents IKs, IKr, ICaL, INCX, INaK, and INaL, and for the increase of INaL during simulated LQT3. Optimizing to APD values only (APDLQT) resulted in a very different parameter set compared to the multi-variable optimization that include of [Ca2+]i and [Na+]i constraints. In particular, it resulted in much increased scalings for ICaL and INaK.