Table 4.
Absolute concentrations of cytokines in peripheral blood mononuclear cell culture supernatant, from elderly subjects in the control dietary intervention group, at pre- and post-intervention.
| Adipokine | Study time point | Media alone | Stimulated | P values | |
|---|---|---|---|---|---|
| Adipsin | Pre-int | Mean (SEM) | 21.28 (9.66) | 25.13 (10.8) | 0.551 (ns) |
| Range | 0–98.29 | 0–91.65 | |||
| Post-int | Mean (SEM) | 96.99 (62.22) | 89.06 (58.75) | 0.076 (ns) | |
| Range | 0–710.70 | 0–669.50 | |||
| MCP-1 | Pre-int | Mean (SEM) | 4.50 (3.02) | 6.81 (4.69) | 0.205 (ns) |
| Range | 0–34.13 | 0–52.88 | |||
| Post-int | Mean (SEM) | 16.48 (6.70) | 29.77 (12.53) | 0.177 (ns) | |
| Range | 0–71.79 | 1.11–121 | |||
| IL-1β | Pre-int | Mean (SEM) | 1.83 (1.01) | 4.58 (2.49) | 0.275 (ns) |
| Range | 0–9.49 | 0–25.03 | |||
| Post-int | Mean (SEM) | 25.69 (17.19) | 29.22 (17.06) | 0.026 | |
| Range | 0–153.70 | 0–158.90 | |||
| IP-10 | Pre-int | Mean (SEM) | 4.59 (1.75) | 3.29 (1.93) | 0.227 (ns) |
| Range | 0–17.14 | 0–21.72 | |||
| Post-int | Mean (SEM) | 1.35 (0.59) | 1.32 (0.60) | 0.963 (ns) | |
| Range | 0–5.17 | 0–5.73 | |||
| CXCL8 | Pre-int | Mean (SEM) | 32.84 (19.74) | 104.4 (52.48) | 0.065 (ns) |
| Range | 0–220.70 | 0–580.50 | |||
| Post-int | Mean (SEM) | 318.5 (185.80) | 552.10 (169.80) | 0.070 | |
| Range | 3.48–1,751 | 4.87–1,668 | |||
| IL-6 | Pre-int | Mean (SEM) | 0.50 (0.50) | 3.90 (2.83) | 0.185 (ns) |
| Range | 0–5.48 | 0–29.38 | |||
| Post-int | Mean (SEM) | 32.38 (22.26) | 33.60 (19.39) | 0.761 (ns) | |
| Range | 0–214.30 | 0–181.10 | |||
| Resistin | Pre-int | Mean (SEM) | 164.90 (100.30) | 183.70 (100.5) | 0.531 (ns) |
| Range | 0–1,028 | 0–869.90 | |||
| Post-int | Mean (SEM) | 309.10 (124.00) | 285.10 (120.70) | 0.124 (ns) | |
| Range | 0–1,245 | 0–1,246 | |||
| TNF-α | Pre-int | Mean (SEM) | 0.09 (0.09) | 16.68 (7.67) | 0.054 (ns) |
| Range | 0–0.96 | 0–75.91 | |||
| Post-int | Mean (SEM) | 2.95 (2.01) | 53.26 (16.63) | 0.016 | |
| Range | 0–18.85 | 0–151 | |||
CXCL8, C-X-C chemokine ligand 8; IL, interleukin; IP-10, interferon gamma inducible protein 10; LPS, lipopolysaccharide; ns, not statistically significant; MCP-1, monocyte chemoattractant protein-1; R848, resiquimod; SEM, standard error of the mean; TNF-α, tumor necrosis factor alpha.