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. 2017 Dec 19;8:1078. doi: 10.3389/fphys.2017.01078

Figure 3.

Figure 3

Pharmacological properties of outward currents in odontoblasts. (A) Representative current traces recorded under gluc-rich ECS and ICS conditions without (second upper traces) and with 10 mM TEA (third upper traces), 10 μM 4-AP (forth upper traces), and 100 nM αDTX (bottom traces) are shown. Currents were evoked by 400 ms voltage-steps from −100 to +80 mV in 10 mV increments from a Vh of −70 mV (upper traces). (B) Dose-response relationships between current amplitudes normalized to those without antagonist and those with various concentration of extracellular antagonist: TEA (upper), 4-AP (middle), and αDTX (lower). Each data point was best fitted using Equation 2, and each IC50 value was evaluated. Each point indicates the mean values ± SD from each 6 cell.