Table 2.
Summary table of complement proteins used in experiments.
| Protein | MW (KDa)a | Diffusion |
Glycosylation | Net chargeb (pH7) | Dynamic radius (nm) | |
|---|---|---|---|---|---|---|
| >70 years old | <35 years old | |||||
| C3 | 180 | No | No | Yes | −11.8 | 4.84 |
| Factor H | 155 | No | No | Yes | −9.6 | 5.56 |
| Factor B | 83 | No | No | Yes | 0.7 | 3.22 |
| Factor I | 65 | No | No | Yes | 2.7 | 3.07 |
| FHL-1 | 49 | Yes | Yes | No | −1.5 | 4.40 |
| Factor D | 24 | Yes | Yes | No | 1.1 | 2.08 |
| C3a | 9 | No | – | No | 9.2 | 1.56 |
| C5a | 8.3 | Yes | – | Yes | 5.2 | 1.63 |
aMW values are based on core protein and do not include the contribution of glycosylation.
bNet charge calculated using protparam v3.4 tool from Expasy (https://web.expasy.org/protparam/).