Figure 8.

Pharmacological inhibition of SPT increases cell susceptibility to apoptosis in wild type STHdh^7/7 cells to the same extent as HD STHdh^111/111 cells. Analysis of apoptosis in STHdh cell lines first cultured for 36 h in complete medium in supplemented or not with 50 μM myriocin and then incubated for 5 h in serum-free medium to induce apoptosis. Values are mean ± SD of two experiments performed in triplicate. For statistical analyses, Two-tailed Unpaired t-test was used; p < 0.05 were considered significant.