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EMAP-II increased the BTB permeability in vivo via down-regulating miR-330-3p orthotopic xenograft model. (A) Contents of evans blue (EB) in tumor-bearing brain after EMAP-II and miR-330-3p lentivirus injection. The expression levels of PKCα (B) and TJ proteins (C) in tumor microvessel segments were detected by qRT-PCR. Values are means ± SD (n = 5, each). *P < 0.05, **P < 0.01 vs. control group; ##P < 0.01 vs. EMAP-II group.
