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. 2017 Dec 19;8:222. doi: 10.3389/fgene.2017.00222

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Copyright © 2017 Sharbati, Bohmer, Bohmer, Keller, Backes, Franke, Steinberg, Zeljenková and Einspanier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmap of differentially expressed genes and GO analysis. Heatmaps showing all differentially expressed genes with more than a twofold up- or down-regulation (q < 0.05) in male (A) and female (B) animals of study B. GO analysis (C,D) of the differentially expressed genes (log2R > 1 or < –1) indicates pathways in which regulated genes show a highly significant enrichment in males (C) or females (D). Networks of protein-protein interactions of males (E) or females (F) showing associations in sets of differentially expressed genes.