Table 1.
SMS composition in different models of senescence.
|
SMS Replicative, genotoxic, and OIS Lasry and Ben-Neriah, 2015 |
SIR Genotoxic Lasry and Ben-Neriah, 2015 |
SMS Genotoxic Gaur et al., 2017b |
|---|---|---|
| BMP6 | BMP6 | |
| CCL1 | CCL1 | |
| CCL8 | CCL8 | |
| Eotaxin 3 | Eotaxin 3 | |
| FAS | FAS | |
| HGF | HGF | |
| ICAM-1 | ICAM-1 | ICAM-1 |
| IGF-1 | IGF-1 | |
| IGFBP4 | IGFBP4 | |
| IL-6 | IL-6 | |
| IL-13 | IL-13 | |
| IL-15 | IL-15 | |
| NAP2 | NAP2 | |
| TGFb1 | TGFb1 | |
| Activin A | Atf5 | CCL5 |
| Amphiregulin | Ccdc33 | CCL17 |
| Angiogenin | CD9 | CCL27 |
| Axl | CD14 | CSF1 |
| bFGF | CD276 | CXCL11 |
| BMP2 | CD40 | Eotaxin 2 |
| CCL2 | Cpa2 | FGF-6 |
| CCL3 | CXCL1 | GDNF |
| CCL7 | CXCL3 | ICAM-2 |
| CCL13 | CXCL5 | IL-3 |
| CCL16 | CXCL9 | IL-5 |
| CD9 | CXCL10 | IL-10 |
| CD55 | ETV5 | IL-16 |
| CSF2 | Faim2 | L-selectin |
| CSF2RB | Fam129a | LAP |
| CXCL1 | Hamp | Leptin |
| CXCL5 | Hif3a | Leptin R |
| EGFR | IFIT1 | PDGF AB |
| ENA78 | IFIT2 | PDGF BB |
| Epiregulin | IFIT3 | PRL |
| Ets2 | IFITM3 | SCF |
| FGF7 | IGF2BP1 | TGFb2 |
| GCP2 | IGFBP1 | TNFSF14 |
| GDF 15 | IL-1a | VEGF R3 |
| GEM | IL-1f9 | |
| GMCSF | IL-1RN | |
| Gmfg | ISG15 | |
| Heregulin | Itga2 | |
| ICAM-3 | Lass3 | |
| IGFBP-1 | Lpo | |
| IGFBP-2 | Mapk11 | |
| IGFBP-6 | Mif | |
| IGFF-2R | Msx2 | |
| IL-1a | MX1 | |
| IL-1b | MX2 | |
| IL-7 | NXN | |
| Inhibin A | OAS2 | |
| IQGAP2 | OAS3 | |
| Itga2 | OLR1 | |
| Itpka | Phlda1 | |
| Jun | Pla2g2a | |
| Mif | Pla2g2f | |
| MMP1 | Prss22 | |
| MMP2 | PTGES | |
| MMP3 | Rel | |
| MMP10 | Runx1 | |
| Osteoprotegerin | SLC7a11 | |
| PAI1 | Sox17 | |
| Pecam1 | Sox4 | |
| PIGF | Tirap | |
| PTGES | TLR1 | |
| RPS6ka5 | TLR2 | |
| Timp2 | TNFRSF19 | |
| uPAR | TNFRSF8 | |
| VEGFa | Tnip2 | |
| VEGFc | USP18 | |
| Wnt2 | Xaf1 |
Comparison of previously reported SMS (Lasry and Ben-Neriah, 2015) to SMS of adipose-derived mesenchymal stem cells induced to acute senescence by genotoxic stress. Column one lists SMS of normal endothelial, epithelial and fibroblast cells reported in Coppe et al. (2008), Kuilman et al. (2008) and Acosta et al. (2013). Column two shows the senescence-associated inflammatory responses (SIR) from intestinal cells (Pribluda et al., 2013). The third from the left column lists SMS from adipose-derived mesenchymal stem cells induced to senescence by bleomycin (Gaur et al., 2017b). Common proteins are highlighted in bold red. Atf5, Activating Transcription Factor 5; Axl, AXL Receptor Tyrosine Kinase; bFGF, Basic Fibroblast Growth Factor; BMP2, Bone Morphogenetic Protein 2; BMP6, Bone Morphogenetic Protein 6; Ccdc33, Coiled-Coil Domain Containing 33; CCL1, Chemokine (C-C Motif) Ligand 1; CCL2, Chemokine (C-C Motif) Ligand 2; CCL3, Chemokine (C-C Motif) Ligand 3; CCL5, Chemokine (C-C Motif) Ligand 5; CCL7, Chemokine (C-C Motif) Ligand 7; CCL8, Chemokine (C-C Motif) Ligand 8; CCL13, Chemokine (C-C Motif) Ligand 13; CCL16, Chemokine (C-C Motif) Ligand 16; CCL17, Chemokine (C-C Motif) Ligand 17; CCL27 (CTACK), C-C Motif Chemokine Ligand 27; CD14, CD14 Molecule, Myeloid Cell-Specific Leucine-Rich Glycoprotein; CD276, CD276 Molecule; CD40, CD40 Molecule; CD55, CD55 Molecule; CD9, CD9 Molecule; Cpa2, Carboxypeptidase A2; CSF2, Colony Stimulating Factor 2; CSF2RB, Colony Stimulating Factor 2 Receptor Beta; CXCL1, C-X-C Motif Chemokine Ligand 1; CXCL3, C-X-C Motif Chemokine Ligand 3; CXCL5, C-X-C Motif Chemokine Ligand 5; CXCL9, C-X-C Motif Chemokine Ligand 9; CXCL10, C-X-C Motif Chemokine Ligand 10; CXCL11, C-X-C Motif Chemokine Ligand 11; EGFR, Epidermal growth factor receptor; ENA78, Epithelial-Derived Neutrophil-Activating Protein 78; Ets2, ETS Proto-Oncogene 2, Transcription Factor; ETV5, ETS Variant 5; Faim2, Fas Apoptotic Inhibitory Molecule 2; Fam129a, Family With Sequence Similarity 129 Member A; FAS, Fas Cell Surface Death Receptor; FGF-6, Fibroblast Growth Factor 6; FGF-7, Fibroblast Growth Factor 7; GCP2, granulocyte chemotactic protein 2; GDF 15, Growth Differentiation Factor 15; GDNF, Glial Cell Derived Neurotrophic Factor; GEM, GTP Binding Protein Overexpressed In Skeletal Muscle; GMCSF, Granulocyte-macrophage colony-stimulating factor; Gmfg, Glia Maturation Factor Gamma; Hamp, Hepcidin Antimicrobial Peptide; HGF, Hepatocyte growth factor; Hif3a, Hypoxia Inducible Factor 3 Alpha Subunit; I-309 (CCL1), T Lymphocyte-Secreted Protein I-309; I-TAC (CXCL11), Interferon-Inducible T-Cell Alpha Chemo-attractant; ICAM-1, Intercellular Adhesion Molecule 1; ICAM-2, Intercellular Adhesion Molecule 2; ICAM-3, Intercellular Adhesion Molecule 3; IFIT1, Interferon Induced Protein With Tetratricopeptide Repeats 1; IFIT2, Interferon Induced Protein With Tetratricopeptide Repeats 2; IFIT3, Interferon Induced Protein With Tetratricopeptide Repeats 3; IFITM3, Interferon Induced Transmembrane Protein 3; IGF-1, Insulin-like growth factor; IGF2BP1, Insulin Like Growth Factor 2 MRNA Binding Protein 1; IGFBP-1, Insulin Like Growth Factor Binding Protein 1; IGFBP-2, Insulin Like Growth Factor Binding Protein 2; IGFBP-4, Insulin Like Growth Factor Binding Protein 4; IGFBP-6, Insulin Like Growth Factor Binding Protein 6; IGFF-2R, Insulin Like Growth Factor 2 Receptor; IL-1a, Interleukin 1 alpha; IL-1b, Interleukin 1 beta; IL-3, Interleukin 3; IL-5, Interleukin 5; IL-6, Interleukin 6; IL7, Interleukin 7; IL-10, Interleukin 10; IL-13, Interleukin 13; IL-15, Interleukin 15; IL-1f9, Interleukin-1 Family Member 9; IL-1RN, Interleukin 1 Receptor Antagonist; IL-16, Interleukin 16; IQGAP2, IQ Motif Containing GTPase Activating Protein 2; ISG15, Interferon-Stimulated Protein, 15 KDa, Ubiquitin-Like Modifier; Itga2, Integrin Subunit Alpha 2; Itpka, Inositol-Trisphosphate 3-Kinase A; Jun, Jun Proto-Oncogene, AP-1 Transcription Factor Subunit; LAP (TGFb1), latency-associated peptide; Lass3, LAG1 Longevity Assurance Homolog 3; Leptin R, Leptin receptor; LIGHT (TNFSF14), Tumor Necrosis Factor Superfamily Member 14; Lpo, Lactoperoxidase; M-CSF (CSF1), Macrophage Colony Stimulating Factor 1; Mapk11, Mitogen-Activated Protein Kinase 11; MCP-2 (CCL8), Monocyte Chemoattractant Protein 2; Mif, Macrophage Migration Inhibitory Factor; MMP1, Matrix Metallopeptidase 1; MMP2, Matrix Metallopeptidase 2; MMP3, Matrix Metallopeptidase 3; MMP10, Matrix Metallopeptidase 10; Msx2, Msh Homeobox 2; MX1, MX Dynamin Like GTPase 1; MX2, MX Dynamin Like GTPase 2; NAP2 (PPBP), Neutrophil-Activating Peptide 2, Platelet Basic Protein; NXN, Nucleoredoxin; OAS2, 2′-5′-Oligoadenylate Synthetase 2; OAS3, 2′-5′-Oligoadenylate Synthetase 3; OLR1, Oxidized Low Density Lipoprotein Receptor 1; PAI1, Phenylalanine ammonia-lyase 1; PDGF AB, Platelet Derived Growth Factor Subunit A beta; PDGF BB, Platelet Derived Growth Factor Subunit b beta; Pecam1, Platelet And Endothelial Cell Adhesion Molecule 1; Phlda1, Pleckstrin Homology Like Domain Family A Member 1; PIGF, Phosphatidylinositol Glycan Anchor Biosynthesis Class F; Pla2g2a, Phospholipase A2 Group IIA; Pla2g2f, Phospholipase A2 Group IIF; PRL, Prolactin; Prss22, Protease- Serine 22; PTGES, Prostaglandin E Synthase; RANTES (CCL5), Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted; Rel, REL Proto-Oncogene, NF-KB Subunit; RPS6ka5, Ribosomal Protein S6 Kinase A5; Runx1, Runt Related Transcription Factor 1; SCF, Stem cell factor; SLC7a11, Solute Carrier Family 7 Member 11; Sox17, SRY-Related HMG-Box Transcription Factor SOX17; Sox4, SRY (Sex Determining Region Y)-Box 4; TARC (CCL17), Thymus And Activation-Regulated Chemokine; TGFb1, Transforming Growth Factor Beta 1; TGFb2, Transforming Growth Factor Beta 2; Timp2, TIMP Metallopeptidase Inhibitor 2; Tirap, TIR Domain Containing Adaptor Protein; TLR1, Toll Like Receptor 1; TLR2, Toll Like Receptor 2; TNFRSF19, Tumor necrosis factor receptor superfamily 19; TNFRSF8, Tumor necrosis factor receptor superfamily 8; Tnip2, TNF Alpha Induced Protein 3 interactive protein 2; uPAR, Plasminogen Activator, Urokinase Receptor; USP18, Ubiquitin Specific Peptidase 18; VEGF R3, Vascular Endothelial Growth Factor receptor 3; VEGFa, Vascular Endothelial Growth Factor A; VEGFc, Vascular Endothelial Growth Factor C; Wnt2, Wingless-Type MMTV Integration Site Family Member 2; Xaf1, X-Linked Inhibitor Of Apoptosis Associated Factor 1.