Figure 3.

IA boost with citrullinated peptides leads to prolonged articular swelling. (A) Animals previously immunized with citrullinated peptides were boosted with IFA alone or citrullinated peptides + IFA in the right knee (upper two panels). Other control groups were (1) naïve animals injected with citrullinated peptides + IFA and (2) rhMOG-primed animals boosted intra-articularly with rhMOG + IFA (lower two panels). Weekly clinical monitoring of both knees is summarized with key time points. Photographs show 90° flexed right knees on the left side of the pictures. (B) Semi-quantitative longitudinal clinical evaluation of knee swelling for each animal with previous prime. Comparison between IFA alone and IA with citrullinated peptides + IFA. IFA, incomplete Freund’s adjuvant; IA, intra-articular; cit, citrullinated; rhMOG, recombinant human myelin oligodendrocyte glycoprotein.