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. 2017 Dec 20;11:413. doi: 10.3389/fncel.2017.00413

Figure 3.

Figure 3

Effect of TRPC6 knockdown on paired-pulse responses in the dentate gyrus and CA1 region. (A) Measurement of the field excitatory postsynaptic potential (fEPSP) slope (EPSP) and population spike amplitude (PS). Filled circles indicate stimulus artifacts. (B) Input–output (IO) curves for the dentate gyrus of control siRNA- and TRPC6 siRNA-infused animals (mean ± SEM; n = 7, respectively). (C) Representative traces of paired-pulse responses in the dentate gyrus of control siRNA- and TRPC6 siRNA-infused animals at 30 ms interstimulus interval at stimulus intensity 2× threshold. (D) Normalized excitability ratio in the dentate gyrus of control siRNA- and TRPC6 siRNA-infused animals. *p < 0.05 vs. control siRNA-infused animals (mean ± SEM; n = 7, respectively). (E) Normalized population spike amplitude ratio in the dentate gyrus of control siRNA- and TRPC6 siRNA-infused animals. *p < 0.05 vs. control siRNA-infused animals (mean ± SEM; n = 7, respectively). (F) Representative traces of paired-pulse responses in the CA1 region of control siRNA- and TRPC6 siRNA-infused animals at 30 ms interstimulus interval at stimulus intensity 2× threshold. (G) Normalized fEPSP amplitude ratio in the CA1 region of control siRNA- and TRPC6 siRNA-infused animals. *p < 0.05 vs. control siRNA-infused animals (mean ± SEM; n = 7, respectively).