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. 2017 Dec 1;24(12):1267–1281. doi: 10.5551/jat.41517

Table 2. Characteristics of study participants for each single nucleotide polymorphism (SNP).

Genotype rs753152
 p value
Major Homo
 Hetero+Minor Homo
n mean ± SD (%) n mean ± SD (%)
Sex (male) 5890 44.8% 447 47.1% 0.188
Age (year) 13137 54.8 ± 9.4 950 55.0 ± 9.5 0.462
BMI (kg/m2) 10578 23.2 ± 3.4 752 23.1 ± 3.5 0.809
Systolic blood pressure (mmHg) 10514 128 ± 20.2 747 128 ± 19.1 0.528
Diastolic blood pressure (mmHg) 10513 78.2 ± 12.3 747 77.9 ± 11.7 0.441
Triglyceride (mg/dl) 10861 128 ± 96.5 792 130 ± 94.0 0.585
Total cholesterol (mg/dl) 9947 211 ± 34.7 749 211 ± 36.0 0.821
nonHDL-C (mg/dl) 9946 148 ± 35.1 749 149 ± 36.1 0.781
HDL-C (mg/dl) 10863 62.7 ± 16.3 792 62.3 ± 15.8 0.458
Hemoglobin A1C (%) 8057 5.55 ± 0.73 581 5.61 ± 0.74 0.055
eGFR (mL/min/1.73 m2) 10509 78.8 ± 15.1 774 78.3 ± 14.9 0.374
Alcohol drinking
    0 g/d 5912 45.8% 433 46.6%
    0.1–22.9 g/d 4224 32.7% 305 32.8%
    23–45.9 g/d 1412 10.9% 101 10.9% 0.870
    46.0+ g/d 1359 10.5% 90 9.7%
Smoking 2471 18.8% 171 18.0% 0.574
Regular physical activity 3830 29.2% 289 30.5% 0.417
Genotype rs77035639
 p value
Major Homo
 Hetero+Minor Homo
n mean ± SD (%) n mean ± SD (%)
Sex (male) 6114 44.9% 223 46.2% 0.609
Age (year) 13604 54.8 ± 9.4 483 54.5 ± 9.3 0.587
BMI (kg/m2) 10937 23.2 ± 3.4 393 23.3 ± 3.2 0.562
Systolic blood pressure (mmHg) 10874 128 ± 20.1 387 128 ± 20.4 0.605
Diastolic blood pressure (mmHg) 10873 78.2 ± 12.2 387 77.6 ± 12.3 0.318
Triglyceride (mg/dl) 11246 128 ± 96.3 407 129 ± 96.0 0.868
Total cholesterol (mg/dl) 10326 211 ± 34.7 370 211 ± 36.1 0.966
nonHDL-C (mg/dl) 10325 148 ± 35.1 370 149 ± 36.5 0.879
HDL-C (mg/dl) 11248 62.7 ± 16.3 407 62.5 ± 15.6 0.795
Hemoglobin A1C (%) 8347 5.55 ± 0.73 291 5.63 ± 0.91 0.171
eGFR (mL/min/1.73 m2) 10899 78.7 ± 15.1 384 78.2 ± 13.8 0.527
Alcohol drinking
    0 g/d 6136 45.9% 209 44.5%
    0.1–22.9 g/d 4376 32.7% 153 32.6%
    23–45.9 g/d 1458 10.9% 55 11.7% 0.856
    46.0+ g/d 1396 10.4% 53 11.3%
Smoking 2548 18.7% 94 19.5% 0.682
Regular physical activity 3985 29.3% 134 27.7% 0.475
Genotype rs3815524
 p value
Major Homo
 Hetero+Minor Homo
n mean ± SD (%) n mean ± SD (%)
Sex (male) 5613 45.0% 724 44.6% 0.750
Age (year) 12464 54.8 ± 9.4 1623 54.7 ± 9.4 0.816
BMI (kg/m2) 10010 23.2 ± 3.4 1320 23.2 ± 3.3 0.950
Systolic blood pressure (mmHg) 9949 128 ± 20.1 1312 128 ± 20.1 0.868
Diastolic blood pressure (mmHg) 9948 78.3 ± 12.2 1312 77.9 ± 12.1 0.374
Triglyceride (mg/dl) 10288 128 ± 96.3 1365 130 ± 96.3 0.447
Total cholesterol (mg/dl) 9426 211 ± 34.8 1270 212 ± 34.2 0.703
nonHDL-C (mg/dl) 9425 148 ± 35.2 1270 149 ± 35.0 0.382
HDL-C (mg/dl) 10289 62.7 ± 16.3 1366 62.3 ± 15.8 0.372
Hemoglobin A1C (%) 7659 5.56 ± 0.74 979 5.55 ± 0.66 0.684
eGFR (mL/min/1.73 m2) 9966 78.8 ± 15.2 1317 78.3 ± 14.1 0.237
Alcohol drinking
    0 g/d 5615 45.8% 730 46.1%
    0.1–22.9 g/d 4007 32.7% 522 32.9%
    23–45.9 g/d 1336 10.9% 177 11.2% 0.848
    46.0+ g/d 1293 10.6% 156 9.8%
Smoking 2345 18.8% 297 18.3% 0.635
Regular physical activity 3655 29.4% 464 28.6% 0.542
Genotype rs75380157
 p value
Major Homo
 Hetero+Minor Homo
n mean ± SD (%) n mean ± SD (%)
Sex (male) 5843 45.5% 494 44.5% 0.777
Age (year) 12978 54.8 ± 9.4 1109 54.6 ± 9.4 0.629
BMI (kg/m2) 10439 23.2 ± 3.4 891 23.0 ± 3.2 0.280
Systolic blood pressure (mmHg) 10377 128 ± 20.1 884 128 ± 20.3 0.845
Diastolic blood pressure (mmHg) 10376 78.3 ± 12.2 884 77.9 ± 12.3 0.367
Triglyceride (mg/dl) 10734 128 ± 96.1 919 129 ± 98.9 0.663
Total cholesterol (mg/dl) 9829 211 ± 34.8 867 211 ± 34.4 0.888
nonHDL-C (mg/dl) 9829 148 ± 35.2 867 149 ± 34.7 0.930
HDL-C (mg/dl) 10735 62.7 ± 16.3 920 62.5 ± 15.6 0.723
Hemoglobin A1C (%) 7954 5.56 ± 0.74 684 5.56 ± 0.71 0.794
eGFR (mL/min/1.73 m2) 10393 78.8 ± 15.2 890 78.1 ± 14.0 0.190
Alcohol drinking
    0 g/d 5841 45.8% 504 46.5%
    0.1–22.9 g/d 4169 32.7% 360 33.2%
    23–45.9 g/d 1393 10.9% 120 11.1% 0.637
    46.0+ g/d 1348 10.6% 101 9.3%
Smoking 2424 18.7% 218 19.7% 0.424
Regular physical activity 3801 29.3% 318 28.7% 0.679
Genotype rs74603859
 p value
Major Homo
 Hetero+Minor Homo
n mean ± SD (%) n mean ± SD (%)
Sex (male) 6044 45.1% 293 43.0% 0.287
Age (year) 13405 54.8 ± 9.4 682 54.8 ± 9.2 0.889
BMI (kg/m2) 10778 23.1 ± 3.4 552 23.6 ± 3.5 0.001
Systolic blood pressure (mmHg) 10711 128 ± 20.1 550 130 ± 20.6 0.020
Diastolic blood pressure (mmHg) 10710 78.2 ± 12.2 550 79.0 ± 12.1 0.137
Triglyceride (mg/dl) 11082 128 ± 95.0 571 133 ± 118 0.192
Total cholesterol (mg/dl) 10183 211 ± 34.8 513 212 ± 34.4 0.871
nonHDL-C (mg/dl) 10182 148 ± 35.2 513 150 ± 34.8 0.393
HDL-C (mg/dl) 11084 62.7 ± 16.3 571 61.9 ± 15.9 0.213
Hemoglobin A1C (%) 8235 5.55 ± 0.72 403 5.59 ± 0.94 0.277
eGFR (mL/min/1.73 m2) 10732 78.7 ± 15.1 551 79.4 ± 14.7 0.302
Alcohol drinking
    0 g/d 6033 45.8% 312 46.7%
    0.1–22.9 g/d 4325 32.8% 204 30.5%
    23–45.9 g/d 1432 10.9% 81 12.1% 0.558
    46.0+ g/d 1378 10.5% 71 10.6%
Smoking 2523 18.8% 119 17.5% 0.392
Regular physical activity 3905 29.2% 214 31.4% 0.210
Genotype rs147565266
 p value
Major Homo
 Hetero+Minor Homo
n mean ± SD (%) n mean ± SD (%)
Sex (male) 6305 45.0% 32 50.8% 0.376
Age (year) 14024 54.8 ± 9.4 63 56.0 ± 8.3 0.312
BMI (kg/m2) 11277 23.2 ± 3.4 53 23.3 ± 3.2 0.739
Systolic blood pressure (mmHg) 11209 128 ± 20.1 52 133 ± 26.2 0.189
Diastolic blood pressure (mmHg) 11208 78.2 ± 12.2 52 79.6 ± 14.6 0.501
Triglyceride (mg/dl) 11599 128 ± 95.9 54 151 ± 161 0.293
Total cholesterol (mg/dl) 10644 211 ± 34.7 52 215 ± 36.6 0.446
nonHDL-C (mg/dl) 10643 148 ± 35.1 52 152 ± 39.1 0.488
HDL-C (mg/dl) 11601 62.7 ± 16.2 54 62.9 ± 21.2 0.950
Hemoglobin A1C (%) 8592 5.56 ± 0.73 46 5.63 ± 0.84 0.520
eGFR (mL/min/1.73 m2) 11230 78.7 ± 15.1 53 80.2 ± 14.2 0.482
Alcohol drinking
    0 g/d 6318 45.9% 27 43.5%
    0.1–22.9 g/d 4513 32.8% 16 25.8%
    23–45.9 g/d 1505 10.9% 8 12.9% 0.226
    46.0+ g/d 1438 10.4% 11 17.7%
Smoking 2632 18.8% 10 15.9% 0.631
Regular physical activity 4105 29.3% 14 22.2% 0.268

Homo, homozygote; Hetero, heterozygote.