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. Author manuscript; available in PMC: 2018 Sep 27.
Published in final edited form as: Chem Rev. 2017 Jun 5;117(18):11894–11951. doi: 10.1021/acs.chemrev.7b00022

Figure 25.

Figure 25

(A) Site selective O–H insertion of 126 with Rh2(OAc)4. 4-bromophenyl-substituted diazo esters were found to give the best selectivity for mono O–H insertion. (B) Expansion of complex molecule substrate scope for site-selective O–H insertion. All compounds give one mono insertion product, with the exception of 147, which gives primarly diether 149. Note: numbers in parantheses represent %RSM. (C) Alteration of dirhodium catalyst perturbs the ratio of the two mono insertion products. Abbrev: HBPA: 5-hexynyl-(α-4-bromophenyl)acetate.172