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. Author manuscript; available in PMC: 2018 Sep 27.
Published in final edited form as: Chem Rev. 2017 Jun 5;117(18):11894–11951. doi: 10.1021/acs.chemrev.7b00022

Figure 32.

Figure 32

(A) Pyridyl-appended imines can function as directing groups for Cu-catalyzed aerobic oxidations of C12–H in steroids. This method tolerates both alcohols and alkenes. (B) The proposed mechanism proceeds via bimetallic activation of O2 to activate the C12–H bond.214