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. Author manuscript; available in PMC: 2018 Sep 27.
Published in final edited form as: Chem Rev. 2017 Jun 5;117(18):11894–11951. doi: 10.1021/acs.chemrev.7b00022

Figure 4.

Figure 4

(A) Pmh-catalyzed acyl transfer. The imidazole (or other N-heterocycles) serves as a nucleophilic catalyst, decomposing the acid anhydride and delivering the acyl group to a substrate hydroxyl. Other functionality on the peptide can bind to the substrate and enforce selectivity. (B) The acetamide of 5 serves as a directing group for peptide 7, resulting in high levels of selectivity for this kinetic resolution by acylation.39 (C) Peptide-based phosphorylation can be accomplished on more complex substrates, such as 8. (D) Peptides utilized in this figure.48