Table 4.
Kidney and heart malondialdehyde levels, nonenzymatic antioxidant levels (TSH), and enzymatic antioxidant activities (glutathione peroxidase, catalase, and superoxide dismutase) in male rat controls or those treated with lithium (Li), cactus cladodes extract (CCE), and cactus cladodes extract + lithium (CCE + Li) during 60 days.
| Parameters | C | Li | CCE | CCE + Li |
|---|---|---|---|---|
| MDA (nmol/mg protein) | ||||
| Heart | 0.58 ± 0.28 | 1.55 ± 0.20∗∗ | 0.54 ± 0.29++ | 1.03 ± 0.08++ |
| Kidney | 2.3 ± 0.12 | 6.12 ± 0.26∗∗ | 2.35 ± 0.3++ | 3.4 ± 0.24++ |
| SOD (U/mg of protein) | ||||
| Heart | 9 ± 0.12++ | 4.01 ± 0.21∗∗ | 9.59 ± 0.42++ | 5.78 ± 0.15+ |
| Kidney | 7.23 ± 0.8 | 3.01 ± 0.12∗∗ | 8.56 ± 0.56++ | 6.9 ± 0.9++ |
| CAT (μmol/min/mg of protein) | ||||
| Heart | 15.22 ± 3.21 | 9.12 ± 2.34∗∗ | 15.89 ± 3.6++ | 14.03 ± 4.2++ |
| Kidney | 13,2 ± 1.7 | 8,02 ± 0.5∗∗ | 14.03 ± 0.45++ | 9.98 ± 0.52+ |
| GPx (μmol GSH oxidized/min/mg of protein) | ||||
| Heart | 6.27 ± 0.28 | 3.61 ± 0.19∗∗ | 5.90 ± 0.53++ | 5.03 ± 0.30++ |
| Kidney | 3,2 ± 0.12 | 1,15 ± 0.10∗∗ | 4.02 ± 0.9++ | 2.90 ± 0.6+ |
| TSH (U/mg protein) | ||||
| Heart | 1.8 ± 0.09 | 0.06 ± 0.1∗∗ | 1.9 ± 0.08++ | 0.09 ± 0.06++ |
| Kidney | 1.52 ± 0.1 | 0.53 ± 0.02∗∗ | 1.65 ± 0.03++ | 0.9 ± 0.12++ |
Values were expressed as mean ± SEM of 6 rats in group; ∗∗p < 0.01 compared with control (C); +p < 0.01, ++p < 0.01 compared with lithium carbonate-treated group (Li).