Figure 2.

Effect of uniaxial tensile loading at 0.1 Hz frequency on matrix organization of ASC-encapsulated 3D collagen scaffolds. (a) SEM images and (b) directionality histograms of ASC-seeded collagen constructs subjected to 7 days of uniaxial loading at 0%, 2%, 4%, and 6% strains at 0.1 Hz frequency. Scale bar in the image represents 100 μm. Sharper and higher peak in the histogram demonstrates a higher degree of orientation of the fibers. The matrix orientation is parallel to the axis of tensile load application.