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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Adv Exp Med Biol. 2017;1033:151–183. doi: 10.1007/978-3-319-66653-2_8

Figure 1. Schematic representation of the intestinal tight junctions proteins and their location.

Figure 1

Tight junctions are protein complexes that span between epithelial cells to form a tight barrier. They are comprised of transmembrane proteins, such as occludin (red) and claudins (purple) and they are connected to the actin cytoskeleton via a zona occludens (ZO-1 and ZO-2 (grey)). The transmembrane receptor JAM (junctional adhesion molecule (blue)) is also found at tight junctions complexes. Abbreviations: JAM, junctional adhesion molecule; ZO, zona occludens.