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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Trends Cell Biol. 2017 Sep 11;28(1):67–76. doi: 10.1016/j.tcb.2017.08.011

Figure 1. Mitochondrial fusion and division.

Figure 1

Tethering and fusion of the mitochondrial outer membrane (OM) is mediated by mitofusin (Mfn) 1 and 2. Inner membrane (IM) fusion is mediated by heterotypic interaction of Opa1 and CL. To initiate mitochondrial division, Drp1 GTPase is recruited to mitochondria via interactions with its receptor proteins located in the outer membrane (e.g., Mff, Mid49/51 and Fis1). Drp1 is then oligomerized into filaments that wrap around the mitochondria. Finally, GTP hydrolysis drives the constriction of Drp1 spirals and severs mitochondria.