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. 2017 Dec 21;8:1861. doi: 10.3389/fimmu.2017.01861

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Copyright © 2017 Solders, Erkers, Gorchs, Poiret, Remberger, Magalhaes and Kaipe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mucosal-associated invariant T (MAIT) cell frequency does not correlate with graft-versus-host disease (GvHD) status following hematopoietic stem cell transplantation. (A) MAIT cells expressed as percentage of CD3⁺ cells, (B) number of MAIT cells/ml of blood, and (C) number of CD3⁺CD161^dim/negTCRVα7.2^dim/neg cells (non-MAIT T cells)/ml of blood compared between patients with GvHD grade 0–1 (n = 16) and grade 2–3 (n = 22). (D) Pie charts with the median proportion of CD4⁺CD8⁻ (CD4), CD4⁺CD8⁺ (double positive, DP), CD4⁻CD8⁺ (CD8), and CD4⁻CD8⁻ (double negative, DN) MAIT cells from patients with GvHD grade 0–1 (n = 11) and 2–3 (n = 4). (E) Proportions of CD4⁺, DP, CD8⁺, or DN MAIT cells compared between patients with GvHD grade 0–1 (n = 11) and 2–3 (n = 4). Horizontal lines in dot plots indicate the median value. Comparisons were made using the Mann–Whitney test.