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Adenosine (ADO) concentration measured in experimental tumors (DS-sarcomas, n = 26) as a function of the tissue oxygenation status. With decreasing mean tumor pO2 values, ADO accumulates in the tumor reaching ~100 µM in severely hypoxic tumors. For comparison, ADO levels in normal tissues are in the range of 10–100 nM (16, 17).
