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. 2017 Dec 21;10:419. doi: 10.3389/fnmol.2017.00419

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Copyright © 2017 Puighermanal, Biever, Pascoli, Melser, Pratlong, Cutando, Rialle, Severac, Boubaker-Vitre, Meyuhas, Marsicano, Lüscher and Valjent.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered HFS-induced long-term potentiation (LTP) in Acb D1-and D2-MSNs of rpS6^P−/− mice. EPSCs were recorded from eGFP positive (D2-MSNs) (A,B) and eGFP negative (D1-MSNs) (C,D) in the Acb (A,C) or in the DS (B,D) of wt/Drd2-eGFP (black circles) and rpS6^P−/−/Drd2-eGFP (magenta open circles) double transgenic mice before and after HFS-induced LTP. Graphs show normalized EPSCs as a function of time and the overlay of averaged (20 trials) traces of AMPAR EPSCs before (1) and after (2) HFS. Scale bars: 50 pA, 20 ms. Symbols represent average of six trials. *p < 0.05; ***p < 0.001 by Student’s t-test (n and p values in Supplementary Table S1:3a–d).