Figure 1.

Epstein–Barr virus (EBV) latency associates with an accelerated decay of vaccine-specific IgG titers. (A) Anti-rubella and (B) anti-measles IgG titers at 2, 5, and 10 years of age. Thick black lines show mean IgG titers over time, along with 95% Wald confidence intervals in blue. Thin gray lines depict (A) rubella-specific (n = 85) and (B) measles-specific (n = 86) IgG titers for each included individual. Mean (C) anti-rubella and (D) anti-measles IgG titer change over time based on EBV and cytomegalovirus (CMV) carrier status resulting in four groups: EBV⁻CMV⁻ (black slope), EBV⁺CMV⁻ (blue slope), EBV⁻CMV⁺ (green slope), and EBV⁺CMV⁺ (red slope). ^#p-values or *p-values were generated after comparison of EBV⁺CMV⁻ or EBV⁻CMV⁺, respectively, with the EBV⁻CMV⁻ (reference) group by linear mixed model analysis.