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. 2017 Dec 21;8:1865. doi: 10.3389/fimmu.2017.01865

Figure 3.

Figure 3

Characteristics of the peripheral B-cell compartment in relation to Epstein–Barr virus (EBV) carriage at 2 and 5 years of age. (A) Representative gating and (B) combined data for the proportions of CD19+ cells among lymphocytes from EBV−, EBV+CMV− or EBV+CMV+ donors. (B) Right panel shows exclusion of CMV+ donors from the EBV− group. (C) Representative gating and (D) combined data for the proportions of naive B-cells among CD19+ cells in EBV−, EBV+CMV−, or EBV+CMV+ donors. (D) Right panel shows exclusion of CMV+ donors from the EBV− group. (E) Representative gating and (F) combined data for the proportions of memory B-cells (MBCs) among CD19+ cells in EBV−, EBV+CMV−, or EBV+CMV+ donors. (F) Right panel shows exclusion of CMV+ donors from the EBV− group. At age 2 years: EBV− [n = 25 in (A,C,E) and n = 13 in (B,D,F)], EBV+CMV− (n = 10 in all graphs), and EBV+CMV+ (n = 10 in all graphs.) At age 5 years: EBV− [n = 15 in (A,C,E) and n = 11 in (B,D,F)], EBV+CMV− (n = 5 in all graphs), and EBV+CMV+ (n = 15 in all graphs).