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. 2017 Dec 21;8:926. doi: 10.3389/fphar.2017.00926

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Copyright © 2017 Li, Zong, Zhang, Zhang, Xu, Liang, Yang, Yong and Qian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The protective effects of orientin relies on eNOS in vitro. NRCMs were pretreated with orientin (30 μM), NAC (2 mM), L-NAME (100 μM), L-VINO (10 μM), or L-Canavanine (1 mM), L-arginine (2 mM) and exposed to hypoxia for 24 h. (A,F) MTT detected the cell viability in the indicated group. (B,G) Annexin V-positive cells in the indicated group. (C,H) The ROS was detected and quantified by DCFH-DA. The levels of SOD (D), NADPH oxidase (E) activity in the indicated group (n = 6); ^∗p < 0.05 vs. vehicle-normoxia; ^#p < 0.05 vs. vehicle-hypoxia.